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OFFICE
Monell Chemical Senses Center |
3500 Market St. |
Philadelphia, PA 19104 |
Office: (215) 898-5885 |
Email: agelperin@monell.org |
EDUCATION
B.A. | 1962 | Carleton College, Northfield, MN |
Ph.D. | 1966 | Laboratory of V. G. Dethier |
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| Institute of Neurological Sciences |
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| University of Pennsylvania |
Postdoc. | 1966-68 | Laboratory of K. D. Roeder |
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| Tufts University |
PROFESSIONAL POSITIONS
Member, Monell Chemical Senses Center, 2001-
Adjunct Professor, Dept. Neuroscience, University of Pennsylvania, 2002-
Member, Institute of Neurological Sciences, University of Pennsylvania, 2002-
Visiting Lecturer, Dept. Molecular Biology, Princeton University, 2000-
Consultant, Biological Computation Research Dept, Bell Labs, 2001-
Associate Member, Graduate Faculty in Physiology and Neurobiology, Rutgers University, 1989-
Lecturer, Methods In Computational Neuroscience course, MBL, Woods Hole, 2000-2002
Member Technical Staff, Biological Computation Research Dept., Bell Labs, 1981-2001.
Visiting Lecturer with Rank of Professor, Department of Biology, Princeton University, 1982-1990.
Chairman, Program in Neuroscience, Princeton University 1975-1982.
Professor, Department of Biology, Princeton University, 1980-1982.
Associate Prof., Dept. of Biology, Princeton University, 1974-1980.
Assistant Prof., Department of Biology, Princeton University, 1968-1974.
Founding Director, Neural Systems and Behavior Course, Marine Biological Laboratory, Woods Hole, Massachusetts, 1977-1979.
Instructor, Experimental Invertebrate Zoology, Marine Biological Laboratory, Woods Hole, Massachusetts, 1968-1972.
Visiting Professor, Friday Harbor Laboratories, University of Washington, 1986.
Visiting Scholar, Lab. of D. Kennedy, Stanford University, 1973-1974.
HONORS AND AWARDS
Grass Fellow in Neurophysiology, 1966, AAAS-Newcomb Cleveland Prize for 1971.
Fellow of Guggenheim Foundation, 1973, Fellow of AAAS, 1978.
SERVICE POSITIONS
Member, Cognitive Functional Neuroscience Review Committee, NIMH, 1994 - 1998
Councilor, International Society for Neuroethology, 1992 - 1998
Member, Board of Scientific Advisors, Whitney Marine Lab, U. FL, 1994 - 1998
Member, International Advisory Council, Olfactory Research Fund, 1999 -
Editorial Board, Learning & Memory, 1996 -, Chemical Senses, 1998-
PATENTS
Awarded: Patent No. 5,675,070 awarded 7 Oct. 1997 to A. Gelperin Olfactory sensor identification system and method
Submitted: Crone, Dodabalapur, Gelperin, Katz,
Vapor Sensors
Bao, Crone, Dodabalapur, Gelperin, Katz
Electronic Odor Sensor
BOOK
Jacobs, B. and Gelperin, A. (1981) Serotonin Neurotransmission and Behavior, MIT Press.
PUBLICATIONS
Gelperin, A. (1966) Control of crop emptying in the blowfly. J. Insect Physiol. 212: 331-345.
Gelperin, A. (1966) Investigations of a foregut receptor essential to taste threshold regulation in the blowfly. J. Insect Physiol. 212: 828-841.
Stay, B. and Gelperin, A. (1966) Physiological basis of ovipositional behavior in the false ovoviviparous cockroach, Pycnoscelus surinamensis . J. Insect Physiol. 212: 1217-1226.
Gelperin, A. and Dethier, V. G. (1967) Long-term regulation of sugar intake by the blowfly. Physiol. Zool. 240: 218-228.
Dethier, V. G. and Gelperin, A. (1967) Hyperphagia in the blowfly. J. Exp. Biol. 247: 191-200.
Gelperin, A. (1967) Stretch receptors in the foregut of the blowfly. Science 157: 208-210.
Gelperin, A. (1968) Feeding behavior of the praying mantis: A learned modification. Nature 219: 399-400.
Gelperin, A. (1971) Regulation of feeding. Ann. Rev. Ent. 16: 365-378.
Gelperin, A. (1971) Abdominal sensory neurons providing negative feedback to the feeding behavior of the blowfly. Z. Vergl. Physiol. 72: 17-31.
Gelperin, A. (1972) Neural control systems underlying insect feeding behavior. Am. Zoologist 12: 489-496.
MacKay, A. and Gelperin, A. (1972) Pharmacology and reflex responsiveness of the heart of the giant garden slug, Limax maximus. Comp. Biochem. Physiol. 43A: 877-896.
Gelperin, A. (1974) Olfactory basis of homing behavior in the giant garden slug, Limax maximus. Proc. Natl. Acad. Sci. USA 71: 966-970.
Chang, J. J., Gelperin, A. and Johnson, F. H. (1974) Intracellularly injected aequorin detects trans-membrane calcium flux during action potentials in an identified neuron from the terrestrial slug, Limax maximus. Brain Research 77: 431-442.
Senseman, D. and Gelperin, A. (1974) Comparative aspects of the morphology and physiology of a single identifiable neuron in Helix aspersa, Limax maximus and Ariolimax californica. Malacological Review 7: 51-52.
Prior, D. and Gelperin, A. (1974) Behavioral and physiological studies on locomotion of the giant garden slug Limax maximus. Malacological Review 7: 50-51.
Gelperin, A. (1974) Neuroethological approach to animal learning. Science 184: 676-677.
Gelperin, A. (1975) Rapid food-aversion learning by a terrestrial mollusk. Science 189: 567-570. Reprinted in "Neurobiology of Learning and Memory", Ed. G. L. Shaw, J. L. McGaugh & S. P. R. Rose, World Scientific, Teaneck, N. J., pp. 480 - 484, 1990.
Gelperin, A. (1975) The comparative study of learning. Science 190: 371-372.
Gelperin, A. and Forsythe, D. (1976) Neuroethological studies of learning in mollusks. In ``Simpler Networks and Behavior'', Ed. J. C. Fentress. Sinauer Associates, Sunderland, Mass. pp. 239-246.
Prior, D. and Gelperin, A. (1977) Autoactive molluscan neuron: Reflex function and synaptic modulation during feeding in the terrestrial slug Limax maximus. J. Comp. Physiol. 114: 217-232.
Sokolove, P. G., Beiswanger, C. M., Prior, D. J. and Gelperin, A. (1977) A circadian rhythm in the locomotor behavior of the giant garden slug Limax maximus. J. Exp. Biol. 66: 46-64.
Gelperin, A., Chang, J. J. and Reingold, S. C. (1978) Feeding motor program in Limax. I. Neuromuscular correlates and control by chemosensory input. J. Neurobiology 9: 285-300.
Gelperin, A. (1978) Neurobiology of Invertebrates. Quart. Rev. Biology 53: 348-349.
Beltz, B. and Gelperin, A. (1979) An ultrastructural analysis of the salivary system of the terrestrial mollusc Limax maximus. Tissue and Cell 11: 31-50.
Reingold, S. C. and Gelperin, A. (1980) Feeding motor program in Limax. II.Modulation by sensory inputs in intact animals and isolated central nervous system. J. Exp. Biol. 85: 1-19.
Beltz, B. and Gelperin, A. (1980) Mechanosensory inputs modulate the activity of salivary and feeding neurons in Limax maximus. J. Neurophysiology 44: 665-674.
Beltz, B. and Gelperin, A. (1980) Mechanisms of peripheral modulation of salivary and feeding neurons in Limax maximus: A presumptive sensory-motor neuron. J. Neurophysiology 44: 675-686.
Chang, J. J. and Gelperin, A. (1980) Rapid taste-aversion learning by an isolated molluscan CNS. Proc. Natl. Acad. Sci., USA 77: 6204-6206.
Sejnowski, T. J., Reingold, S. C., Kelley, D. B. and Gelperin, A. (1980)
Localization of 3H-2-deoxyglucose in single molluscan neurons. Nature 287: 449-451.
Reingold, S. C. and Gelperin, A. (1980) Central pattern generators and neuroethology. The Behavior and Brain Sciences 3: 560-561.
Gelperin, A. (1981) Synaptic modulation by identified serotonin neurons. In ``Serotonin Neurotransmission and Behavior'', Eds. B. Jacobs and A. Gelperin. MIT Press. pp. 288-304.
Sahley, C., Gelperin, A. and Rudy, J. (1981) One-trial associative learning modifies food odor preferences of a terrestrial mollusc. Proc. Natl. Acad. Sci. USA 78: 640-642.
Gelperin, A. and Reingold, S. C. (1981) Plasticity of feeding responses emitted by the isolated brain of a terrestrial mollusk. In: Advances in Physiological Sciences, Vol. 23, ``Neurobiology of Invertebrates'', Ed. J. Salanki. Pergamon Press, N.Y. pp. 249-266.
Sahley, C., Gelperin, A. and Rudy, J. (1981) Associative learning in the terrestrial mollusc Limax maximus: A model system in which to study the neural basis of associative learning. In: ``Advances in Physiological Sciences, Vol. 23, ``Neurobiology of Invertebrates'', Ed. J. Salanki. Pergamon Press, N.Y. pp. 267-284.
Egan, M. E. and Gelperin, A. (1981) Olfactory inputs to a bursting serotonergic interneuron in a terrestrial mollusc. J. Molluscan Studies 47: 80-88.
Reingold, S. C., Sejnowski, T. J., Gelperin, A. and Kelley, D. B. (1981) 3H-2-Deoxyglucose autoradiography in a molluscan nervous system. Brain Research 208: 416-420.
Sahley, C., Rudy, J. W. and Gelperin, A. (1981) An analysis of associative learning in a terrestrial mollusc: Higher-order conditioning, blocking and a transient US pre-exposure effect. J. Comp. Physiol. 144:1-8.
Barry, S. R. and Gelperin, A. (1982) Exogenous choline augments transmission at an identified cholinergic synapse in the terrestrial mollusc, Limax maximus. J. Neurophysiology 48: 439-450.
Barry, S. R. and Gelperin, A. (1982) Dietary choline augments blood choline and cholinergic transmission in the terrestrial mollusc, Limax maximus. J. Neurophysiology 48: 451-457.
Culligan, N. and Gelperin, A. (1983) One-trial associative learning by an isolated molluscan CNS: Use of different chemoreceptors for training and testing. Brain Research 266: 319-327.
Copeland, J. and Gelperin, A. (1983) Feeding and a serotonergic interneuron activate an identified autoactive salivary neuron in Limax maximus. Comp. Biochem. Physiol. 76A: 21-30.
Gelperin, A. (1983) Neuroethological studies of associative learning in feeding control systems. In: ``Neuroethology and Behavioral Physiology'', Eds. F. Huber and H. Markl, Springer-Verlag, pp 189-205.
Wieland, S. J. and Gelperin, A. (1983) Dopamine elicits feeding motor program in Limax maximus. J. Neurosci. 3: 1735-1745.
Gelperin, A., Wieland, S. J. and Barry, S. R. (1984) Cellular studies of associative learning in Limax. In: ``Primary Neural Substrates of Learning and Behavioral Change'', Eds. J. Farley and D. Alkon, Cambridge University Press, pp. 229-242.
Sahley, C., Rudy, J. W. and Gelperin, A. (1984) Associative learning in a mollusc: A comparative analysis. In : ``Primary Neural Substrates of Learning and Behavioral Change'', Eds. J. Farley and D. Alkon, Cambridge University Press, pp. 243-258.
Gelperin, A. and Culligan, N. (1984) In vitro expression of in vivo learning by an isolated molluscan CNS. Brain Research 304: 207-213.
Barry, S. R. and Gelperin, A. (1984) Acetylcholine turnover in an autoactive molluscan neuron. Cell. Mol. Neurobiol. 4: 15-29.
Geschwind, M. and Gelperin, A. (1984) Techniques for isolation of abdominal ganglion neurons of Limax maximus. J. Cornell Scientists 1: 6-13.
Cooke, I., Delaney, K., Gelperin, A. (1985) Complex computation in a small neural network. In:``Memory Systems of the Brain: Animal and Human Cognitive Processes'', Ed. N. M. Weinberger, J. L. McGaugh, G. Lynch, Guilford Press, N.Y., pp. 173-192.
Gelperin, A., Hopfield, J. J., Tank, D. W. (1985) The logic of Limax learning. In: ``Model Neural Networks and Behavior'', Ed. A. I. Selverston, Plenum Press, N.Y., pp. 237-261.
Sahley, C. L., Barry, S. R. and Gelperin, A. (1986) Dietary choline augments associative memory function in Limax maximus. J. Neurobiology 17: 113-120.
Gelperin, A. (1986) Complex associative learning in small neural networks. Trends in Neurosciences 9: 323-328.
Gelperin, A. (1986) Plasticity in control systems for insect feeding behavior. In: ``Perspectives In Chemoreception and Behavior'', Ed. E. Bernays and R. F. Chapman, Springer-Verlag, N.Y., pp. 33-46.
Delaney, K. and Gelperin, A. (1986) Post-ingestive food-aversion learning to amino acid deficient diets by the terrestrial slug Limax maximus. J. Comp. Physiol. A, 159: 281-295.
Wieland, S. J., Jahn, E., Gelperin, A. (1987) Localization and synthesis of monoamines in regions of Limax CNS controlling feeding behavior. Comp. Biochem. Physiol. C, 86: 125-130.
Yamane, T. and Gelperin, A. (1987) Aminergic and peptidergic amplification of intracellular cyclic AMP levels in a molluscan neural network. Cell Mol. Neurobiol. 7: 291-301.
King, M. S., Delaney, K., Gelperin, A. (1987) Acetylcholine activates cerebral interneurons and feeding motor program in Limax maximus. J. Neurobiol.18: 509-530.
Cooke, I. and Gelperin, A. (1988) Distribution of GABA-like immunoreactive neurons in the slug Limax maximus. Cell Tissue Research 253:77-81.
Cooke, I. and Gelperin, A. (1988) Distribution of FMRFamide-like immunoreactivity in the nervous system of the slug Limax maximus. Cell Tissue Research 253:69-76.
Gelperin, A., Tank, D. W. and Tesauro, G. (1989) Olfactory processing and associative memory: Cellular and modeling studies. In: ``Neural Models of Plasticity: Theoretical and Empirical Approaches'', Eds. J. H. Byrne and W. O. Berry, Academic Press, N.Y., pp 133-159.
Hopfield, J. F. and Gelperin, A. (1989) Differential conditioning to a compound stimulus and its components in the terrestrial mollusc Limax maximus. Behavioral Neuroscience 103:329-333.
Wieland, S. J., Jahn, E., Gelperin, A. (1989) Release of dopamine and serotonin from Limax ganglia in vitro. Comp. Biochem. Physiol. C, 94:183-188.
Yamane, T., Oestreicher, A. B., Gelperin, A. (1989) Serotonin-stimulated biochemical events in the procerebrum of Limax. Cell. Mol. Neurobiol., 9:447-459.
Gelperin, A. (1989) Neurons and networks for learning about odors. In: ``Perspectives in Neural Systems and Behavior'', Eds. T. J. Carew and D. B. Kelley, A. R. Liss, N.Y., pp. 121-136.
McGuire, T. R., Tully, T., Gelperin, A. (1990) Conditioning odor-shock associations in the black blowfly, Phormia regina. J. Insect Behavior, 3:49-59.
Delaney, K. and Gelperin, A. (1990) Cerebral interneurons controlling fictive feeding in Limax maximus. I. Anatomy and criteria for re-identification. J. Comp. Physiol. A 166:297-310.
Delaney, K. and Gelperin, A. (1990) Cerebral interneurons controlling fictive feeding in Limax maximus II. Initiation and modulation of fictive feeding. J. Comp. Physiol. A 166:311-326.
Delaney, K. and Gelperin, A. (1990) Cerebral interneurons controlling fictive feeding in Limax maximus III Integration of sensory inputs. J. Comp. Physiol. A 166:327-343.
Gelperin, A. and Tank, D. W. (1990) Odor-modulated collective network oscillations of olfactory interneurons in a terrestrial mollusc. Nature, 345:437-440.
Sahley, C. L., Martin, K. A., Gelperin, A. (1990) Analysis of associative learning in the terrestrial mollusc Limax maximus II. Appetitive learning. J. Comp. Physiol. A, 167: 339 - 345.
Gelperin, A. (1990) A taste for learning. Amer. Zool., 30: 549 - 558.
Wong, M., Delaney, K. and Gelperin, A. (1991) Opiate agonists activate feeding in Limax: Comparison of in vivo and in vitro effects. Behavioral Neuroscience 105: 15 - 24.
Gietzen, D. W., Harris, A. S. Carlson, S., Gelperin, A. (1992) Amino acids and serotonin in Limax maximus after a trytophan devoid diet. Comp. Biochem. Physiol. 101A:143-149.
Sahley, C. L., Martin. K. A., Gelperin, A. (1992) Odor input induces feeding motor responses in the terrestrial mollusc Limax maximus. Behavioral Neuroscience 106: 563-568.
Gelperin, A. (1992) Associative learning inLimax . In: Encyclopedia of Learning and Memory, Ed. L. R. Squire, Macmillan Pub. Co., New York, 298-302.
Gelperin, A., Rhines, L., Flores, J., Tank, D. W. (1993) Coherent network oscillations by olfactory interneurons : Modulation by endogenous amines. J. Neurophysiol., 69;1930-1939
Rhines, L., Sokolove, P., Flores, J., Tank, D. W., Gelperin, A. (1993)
Cultured olfactory interneurons from Limax maximus: Optical and electrophysiological studies of transmitter-evoked responses. J. Neurophysiol. 69:1940-1947
Kleinfeld, D., Delaney, K. R., Fee, M. S., Flores, J. A., Tank, D. W., Gelperin, A. (1994) Dynamics of propagating waves in the olfactory network of a terrestrial mollusk: An electrical and optical study. J. Neurophysiol. 72: 1402-1419.
Delaney, K. R., Gelperin, A., Fee, M. R., Flores, J. A., Gervais, R., Tank, D. W. and Kleinfeld, D. (1994) Propagating waves and stimulus-modulated dynamics in an oscillating olfactory network. Proc. Natl. Acad. Sci. USA, 91: 669-673.
Gelperin, A. (1994) Nitric oxide mediates network oscillations of olfactory interneurons in a terrestrial mollusc. Nature 369: 61-63.
Denk, W., Delaney, K. R., Gelperin, A., Kleinfeld, D., Strowbridge, B. W., Tank, D. W., Yuste, R. (1994) Anatomical and functional imaging of neurons using 2-photon laser scanning microscopy. J. Neurosci. Methods 54: 151-162.
Tank, D. W., Gelperin, A., Kleinfeld, D. (1994) Odors, oscillations, and waves: Does it all compute? Science 265:1819-1820.
Gelperin, A. (1994) Nitric oxide, odour processing and plasticity. Netherlands J. Zoology 44: 159-169.
Gelperin, A., Kleinfeld, D., Denk, W., Cooke, I. R. C. (1996) Oscillations and gaseous oxides in invertebrate olfaction. J. Neurobiol. 30:110-122.
Gelperin, A. (1996) Learning, memory, and neural networks: Introduction. Biol. Bull. 191:60-61.
Gelperin, A. (1996) Flies, genes, and memory engineering. Biol. Bull., 191: 139-143.
Gervais, R., Kleinfeld, D, Delaney, K. R., Gelperin, A. (1996) Central and reflex neuronal responses elicited by odor in a terrestrial mollusc. J. Neurophysiol. 76:1327-1339.
Gelperin, A. and Flores, J. A. (1997) Vital staining from dye-coated microprobes identifies new olfactory interneurons for optical and electrical recording. J. Neurosci. Methods, 72:97-108
Ermentrout, B., Flores, J., Gelperin, A. (1998) Minimal model of oscillations and waves in the Limax olfactory lobe with tests of the model's predictive power. J. Neurophysiol. 79:2677-2689.
Gelperin, A. (1998) Cellular and computational analysis of olfactory learning, oscillations and waves. In: Design and Architecture of Information Processing Systems Based on Brain Information Principles, Ed. Sawada, Y., Research Institute of Electrical Communication, Tohoku University, Sendai, Japan, 60-66.
Teyke, T. and Gelperin, A. (1999) Olfactory oscillations augment odor discrimination not odor identification by Limax CNS. NeuroReport 10:1061-1068.
Gelperin, A. (1999) Oscillatory dynamics and information processing in olfactory systems. J. Exp. Biol. 202:1855-1864.
Gelperin, A., Dawson, J. L., Cazares, S. M., Seung, S. H. (1999) Rapid fruit cultivar identification by an artificial olfactory system. In: Electronic Noses & Sensor Array Based Systems, W. J. Hurst, Ed., Technomic Pub. Co, Lancaster, PA, pp. 263-274.
Gelperin, A., Flores, J., Raccuia-Behling, F., Cooke, I. (2000) Nitric oxide and carbon monoxide modulate oscillations of olfactory interneurons in a terrestrial mollusk. J. Neurophysiology 83:116-127.
Teyke, T., Wang, J., Gelperin, A. (2000) Lateralized memory storage and crossed inhibition during odor processing by Limax. J. Comp. Physiol. A, 186:269-278.
Cooke, I. R. C. and Gelperin, A. (2001) In vivo recordings of spontaneous and odor-modulated dynamics in the Limax olfactory lobe. J. Neurobiol. 46:126-141.
Wang, J., Flores, J., Gelperin, A., and Denk, W., (2001) Initiation and propagation of calcium-dependent action potentials in a coupled network of olfactory interneurons. J. Neurophysiol., 85:977-985.
Ermentrout, B., Wang, J. W., Flores, J. and Gelperin, A. (2001) Model for olfactory discrimination and learning and memory in the Limax procerebral lobe incorporating oscillatory dynamics and wave propagation. J. Neurophysiol. 85: 1444-1452.
Crone, B., Dodabalapur, A., Gelperin, A., Torsi, L., Katz, H.E., Lovinger, R., Bao, Z. (2001) Odor sensing and recognition with organic field-effect sensors and circuits. Applied Physics Letters78: 2229-2231.
Gelperin, A. (2001) Smelling well with a code in the nodes. Neuron 30: 307-309.
Gelperin, A., Kao, J.P.Y. and Cooke, I.R.C.. (2001). Gaseous oxides and olfactory computation. Amer. Zool. 41:332-345.
Fujie, S., Aonuma, H., Ito, I., Gelperin, A., Ito, E. (2002) The nitric oxide/cyclic GMP pathway in the olfactory processing system of the terrestrial slug Limax marginatus. Zool.
Sci. 19:15-26.
Gelperin, A. and Hopfield, J.J. (2002) Electronic and computational olfaction. In P. Given (ed.) Chemistry of Taste, American Chemical Society, Washington, DC., pp.289-317
Crone, B.K., Dodabalapur, A., Sarpeshkar, R., Gelperin, A., Katz, H.E., Bao, Z. (2002) Organic oscillator and adaptive amplifier circuits for chemical vapor sensing. Appl. Physics Lett., 91: 10140-10146.
Someya, T., Dodabalapur, A., Gelperin, A., Katz, H. E., Bao, Z. (2002) Integration and response of organic electronics with aqueous microfluidics. Langmuir, 18:5299-5302.
Gelperin, A. (2002) Invertebrate Learning: Associative learrning in Limax. In: Learrning and Memory, 2nd. Edition, Ed. J. Byrne, Macmillian Pub. Co., NY, pp. 281-287.
Ermentrout, B., Wang, J. W., Flores, J., Gelperin, A. (2002) Model for transition from waves to synchrony in the olfactory lobe of Limax. Manuscript submitted.
Someya, t., Katz, H. E., Gelperin, A., Lovinger, A.J., Dodabalapur, A. (2002) Vapor sensing with a, w-dihexylquarterthiphene field-effect transistors: the role of grain boundaries. Appl. Physics Lett., in press.
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