Charles Christopher Horn

 

 

 

 

 

 

 

 

 

 

 

Education

 

1996-2000            Post-Doc, Columbia University (Neurobiology)

1996                       Ph.D., Kansas State University (Behavioral Neuroscience)

1993                       M.S., Kansas State University (Behavioral Neuroscience)

1991                                             B.S., Missouri State University (Psychology)

 

Positions held

 

2008-present        Associate Member (Principal Investigator), Monell Chemical Senses Center

 

2004-2008            Assistant Member (Principal Investigator), Monell Chemical Senses Center

 

2004-present        Member, Institute of Neurological Sciences, University of Pennsylvania

 

2004-present        Member, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania,

                                     School of Medicine 

        

2003-present        Adjunct Assistant Professor of Pharmacology-Toxicology, University of the Sciences

                                    in Philadelphia

 

2000-2004            Research Associate, Monell Chemical Senses Center

 

1997-2000            Instructor in neuroanatomy, Columbia University, College of Physicians and Surgeons

 

1996- 2000            Postdoctoral Fellow, Columbia University,  Center for Neurobiology and Behavior

                                (Dr. Irving Kupfermann, advisor)

                               

1993-1996             Pre-doctoral Fellow,Monell Chemical Senses Center                                                 

                                 (Dr. Mark Friedman, advisor)                                                                                         

 

1992-1994             Graduate Teaching Assistant,Kansas State University, Department of Psychology

                                 Experimental Methods, Psychobiology, and General Psychology courses.

 

Affiliations

 

Society for Neuroscience, 1992-present

Society for the Study of Ingestive Behavior, 1992-present

American Physiological Society, 1997-present

American Association for the Advancement of Science, 2001-present

International Society for Autonomic Neuroscience, 2004-present

International Behavioral Neuroscience Society, 2004-present

 

Research Grants

 

2007-2009            “Mechanisms for detection of Amino acids by hepatic and gastrointestinal vagal and spinal afferent fibers,” Ajinomoto Amino Acid Research Program, (C.Horn, PI)

 

2004-2009            “Neural Basis of Learned Food Aversion and Nausea,” (R01), NIH/NIDDK (C. Horn, PI)

 

2000-2003            “Control of Feeding Behavior: Hepatic afferent signaling, “ Research Scientist Development Award (K01), NIH/NIDDK (C. Horn, PI)

 

1998-1999            “Behavioral and Neural Analysis of Feeding in Aplysia,” National Research Service Award (F32), NIH/NIMH postdoctoral fellowship (C. Horn, PI)

 

Publications

 

Horn, C.C. and Mitchell, J.C. Does selective vagotomy affect conditioned flavor-nutrient preferences in rats? Physiology and Behavior. 59:33-38, 1996.  Abstract

 

Horn, C.C., Tordoff, M.G., and Friedman, M.I. Does ingested fat produce satiety? American Journal of Physiology 27b0:R761-R765, 1996.  Abstract

 

Horn, C.C. and Friedman, M.I. 2,5-Anhydro-D-mannitol induces Fos-like immunoreactivity hindbrain and forebrain: relationship to eating behavior, Brain Research:779:17-25, 1998.  Abstract

 

Horn, C.C. and Friedman, M.I. Methyl palmoxirate increases eating behavior and brain Fos‑like immunoreactivity in rats, Brain Research 781:8-14, 1998.  Abstract

 

Horn, C.C. and Friedman, M.I. Metabolic inhibition increases feeding and brain Fos-like immunoreactivity as a function of diet. American Journal of Physiology. 275:R448-R459, 1998.  Abstract

 

Horn, C.C., Kaplan, J.M., Grill, H.J., and Friedman, M.I. Brain Fos-like immunoreactivity in chronic decerebrate and neurologically intact rats given 2,5-anhydro-D-mannitol. Brain Research 801:107-115, 1998.  Abstract

 

Horn, C.C., Koester, J., and Kupfermann, I. Evidence that hemolymph glucose in Aplysia californica is regulated but does not affect feeding behavior. Behavioral Neuroscience 112:1-8, 1998. Abstract

 

Horn, C.C., Addis, A., and Friedman, M.I. Neural substrate for an integrated metabolic control of feeding behavior. American Journal of Physiology 276:R113‑R119, 1999.  Abstract

 

Horn, C.C., Benjamin, P.R., Weiss, K.R., and Kupfermann, I. Decrement of the response of a serotonergic modulatory neuron (the MCC) in Aplysia, during repeated presentation of appetitive (food) stimuli. Neuroscience Letters 267:161-164, 1999. Abstract

 

Floyd, P.D., Li, L., Rubakhin, S.S., Sweedler, J.V., Horn, C.C., Kupfermann, I., Alexeeva, V.Y., Ellis, T.A., Dembrow, N.C., Weiss, K.R., Vilim, F.S. Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica. Journal of Neuroscience 19:7732-7741, 1999. Abstract

 

Horn, C.C., Tordoff, M.G., and Friedman, M.I. Role of vagal afferent innervation in feeding and brain Fos expression produced by metabolic inhibitors. Brain Research 919:198-206, 2001. Abstract

 

Horn, C.C., Geizhals, C.R., and Kupfermann, I. Further studies of bulk and orosensory decrement in producing satiation of feeding in Aplysia. Brain Research 918:51-59, 2001.  Abstract

 

Horn, C.C. and Kupfermann, I. Egestive feeding responses in Aplysia persist after sectioning of the cerebral-buccal connectives: Evidence for multiple sites of control of motor programs. Neuroscience Letters 323:175-178, 2002. Abstract

 

Horn, C.C. and Friedman, M.I. Detection of single unit activity from the rat vagus using cluster analysis of principal components. Journal of Neuroscience Methods 122:141-147, 2003.Abstract

 

Horn, C.C., Ji, H., and Friedman, M.I. Etomoxir, a fatty acid inhibitor, increases food intake and reduces hepatic energy status in rats. Physiology and Behavior 81:157-162, 2004.Abstract

 

Horn, C.C., Zhurov, Y., Orekhova, I.V., Proekt, A., Kupfermann, I., Weiss, K.R., and Brezina, V. Cycle-to-cycle variability of neuromuscular activity in Aplysia feeding behavior. Journal of Neurophysiology, 92:157-180,    2004.Abstract

 

Horn, C.C. and Friedman, M.I. Separation of Hepatic and Gastrointestinal Signals from the Common "Hepatic" Branch of the Vagus. American Journal of Physiology (Regulatory, Comparative and Integrative Physiology) 287:R120-R126, 2004.Abstract

 

Horn, C.C., Richardson, E.J., Andrews, P.L.R., and Friedman, M.I. Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anti-cancer agent cisplatin. Autonomic Neuroscience: Basic and Clinical 115:74-81, 2004.Abstract

 

Brezina, V., Horn, C.C., and Weiss, K.R. Modeling neuromuscular modulation in Aplysia. III. Interaction of central motor commands and peripheral modulatory state for optimal behavior. Journal of Neurophysiology 93:1523-1556, 2005.Abstract

 

Friedman, M.I., Horn, C.C., and Ji, H. Peripheral signals in the control of feeding behavior.  Chemical Senses 30:i182-i183, 2005.Abstract

 

Horn, C.C. and Friedman, M.I. Thoracic cross-over pathways of the rat vagal trunks. Brain Research, 1060: 153 – 161, 2005.Abstract

 

Andrews, P.L.R. and Horn, C.C. Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. Autonomic Neuroscience: Basic and Clinical, 125:100-115, 2006.Abstract

 

Horn, C.C., Ciucci, M., and Chaudhury, A. Brain Fos expression during 48 h after cisplatin treatment: Neural  pathways for acute and delayed visceral sickness. Autonomic Neuroscience: Basic and Clinical, 132:44-51, 2007. Abstract

 

Jing, J., Vilim, F.S., Horn, C.C., Alexeeva, V., Hatcher, N.G., Sasaki, K., Yashina, I., Zhurov, Y., Kupfermann, I., Sweedler, J.V., and Weiss, K.R.  From Hunger to Satiety: Reconfiguration of a Feeding Network by Aplysia Neuropeptide Y.  Journal of Neuroscience, 27:3490-502, 2007. Abstract

 

Garcia-Medina, N.E., Jimenez-Capdeville, M.E., Ciucci, M., Martinez, L.M., Delgado, J.M., and Horn, C.C. Conditioned Flavor Aversion and Brain Fos Expression Following Exposure to Arsenic. Toxicology, 235:73-82, 2007. Abstract

 

Horn, C.C. Why is the neurobiology of nausea and vomiting so important? Appetite (Elsevier) (in press) Abstract.

 

Horn, C.C.  Is there a need to identify new anti-emetic drugs? Drug Discovery Today: Therapeutic Strategies (in press). Abstract

 

De Jonghe, B.C., and Horn, C.C.  Chemotherapy-induced pica and anorexia are reduced by common hepatic branch vagotomy in the rat. American Journal of Physiology (Regulatory, Comparative and Integrative Physiology), 2008, (in press). Abstract